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From the start of the trial to the end of Week 33, discontinuations due to an adverse reaction occurred in 7 (6%) patients in the Ezetimibe coadministered with simvastatin group and in 2 (2%) patients in the monotherapy group.

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This combination could be a better strategy not only for exerting good lipid-lowering effect on LDL-C, but also for mitigating the adverse effects of lipid-lowering drugs on PCSK9 in controlling dyslipidemia and atherosclerosis.

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Mosca, and other cardiologists interviewed by MedPage Today applauded the study results as a "proof of the LDL theory" -- that low is good, but lower is better.

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The guidelines, although also controversial, really focus on supporting the clinical trials conducted to date that have emphasized the use of maximal lipid-lowering therapies.

Canadian Working Group Consensus Conference concluded that the available evidence "is not strongly supportive of a major adverse effect of statins".

Animal reproduction studies of simvastatin in rats and rabbits showed no evidence of teratogenicity.

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There are also data to suggest that blockade of the renin-angiotensin system () may lower the risk of developing diabetes, but more studies are necessary before these drugs can be recommended for preventing diabetes.

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Baseline CPK measurement is reasonable for some individuals (eg, family history of statin intolerance or muscle disease, clinical presentation, concomitant drug therapy that may increase risk of myopathy).

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Thereafter, screening guidelines and treatment recommendations for hypertension, dyslipidemia, albumin excretion, and retinopathy in youth with type 2 diabetes are similar to those for youth with type 1 diabetes.

However, the ADVANCE trial had no specified targets for the randomized comparison and the mean SBP in the intensive group (135 mmHg) was not as low as the mean SBP even in the ACCORD standard-therapy group ().

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In a rat model, where the glucuronide metabolite of Ezetimibe (SCH 60663) was administered intraduodenally, the metabolite was as potent as the parent compound (SCH 58235) in inhibiting the absorption of cholesterol, suggesting that the glucuronide metabolite had activity similar to the parent drug.

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If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

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In light of these findings and a review of interim data on the other outcomes that were available to them (but that remain unavailable to the investigators and all others), the independent data and safety monitoring committees of both SHARP and IMPROVE-IT have recommended that those trials continue to their scheduled end dates early in the next decade.

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About half the apparent excess incidence of cancer in the SEAS trial was observed within 2 years after treatment was started, during which period there were more than five times the number of patients with cancer in SHARP and IMPROVE-IT as in the SEAS study, without any apparent excess ().

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Of the prespecified secondary end points, only stroke and nonfatal stroke were statistically significantly reduced by intensive blood pressure treatment.

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Ultimately, the study found no significant difference in the study's primary endpoint between those taking the combination drug and those taking placebo.

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Not only are statins effective in normalizing all aspects of your cholesterol profile, they have been also noted to prevent death and complications due to cardiovascular disease.

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Nervous system side effects including dizziness, paresthesia, and headache have been associated with ezetimibe in postmarketing experience.

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