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For those who are unable to take statin drugs due to allergies or sensitivities to statins, such as muscle pain or liver inflammation, alternative drugs are recommended, such as the non-statin drug Zetia (ezetimibe) from Merck and Co.
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In more general terms, the beneficial effect of simvastatin as observed in large clinical trials (4S, HPS) may be related in part to cholesterol-independent effects, suggesting that how cholesterol is reduced may be important.
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Information on presence of urine albumin excretion in addition to level of GFR may be used to stage CKD according to the National Kidney Foundation.
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From the start of the trial to the end of Week 33, discontinuations due to an adverse reaction occurred in 7 (6%) patients in the Ezetimibe coadministered with simvastatin group and in 2 (2%) patients in the monotherapy group.
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However, lipid-lowering therapy reduced the risk of ischemic cardiovascular events, especially the need for CABG.
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Your doctor may do blood tests to check your liver before you start taking ezetimibe with a statin and during treatment.
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This combination could be a better strategy not only for exerting good lipid-lowering effect on LDL-C, but also for mitigating the adverse effects of lipid-lowering drugs on PCSK9 in controlling dyslipidemia and atherosclerosis.
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To put it differently generics have identical active ingredients and their pharmacological effects are the same, as those of their brand-name equivalents.
Ballantyne CM, Houri J, Notarbartolo A et al for the Ezetimibe Study Group.
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It was concluded that, overall, intensive insulin therapy increased the risk of hypoglycemia but provided no overall benefit on mortality in the critically ill, although a possible mortality benefit to patients admitted to the surgical ICU was suggested.
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Mosca, and other cardiologists interviewed by MedPage Today applauded the study results as a "proof of the LDL theory" -- that low is good, but lower is better.
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The guidelines, although also controversial, really focus on supporting the clinical trials conducted to date that have emphasized the use of maximal lipid-lowering therapies.
Canadian Working Group Consensus Conference concluded that the available evidence "is not strongly supportive of a major adverse effect of statins".
Animal reproduction studies of simvastatin in rats and rabbits showed no evidence of teratogenicity.
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There are also data to suggest that blockade of the renin-angiotensin system () may lower the risk of developing diabetes, but more studies are necessary before these drugs can be recommended for preventing diabetes.
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The FDA has become increasingly concerned about the use of POC blood glucose meters in the hospital and is presently reviewing matters related to their use.
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Baseline CPK measurement is reasonable for some individuals (eg, family history of statin intolerance or muscle disease, clinical presentation, concomitant drug therapy that may increase risk of myopathy).
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Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia.
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Thereafter, screening guidelines and treatment recommendations for hypertension, dyslipidemia, albumin excretion, and retinopathy in youth with type 2 diabetes are similar to those for youth with type 1 diabetes.
However, the ADVANCE trial had no specified targets for the randomized comparison and the mean SBP in the intensive group (135 mmHg) was not as low as the mean SBP even in the ACCORD standard-therapy group ().
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In a rat model, where the glucuronide metabolite of Ezetimibe (SCH 60663) was administered intraduodenally, the metabolite was as potent as the parent compound (SCH 58235) in inhibiting the absorption of cholesterol, suggesting that the glucuronide metabolite had activity similar to the parent drug.
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If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.
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According to another aspect, the present invention provides a formulation of ezetimibe, comprising ezetimibe combined with at least two types of hydrophilic excipients, wherein one type of hydrophilic excipient is starch and the other type of hydrophilic excipient is selected from saccharides including mono-saccharides, disaccharides and cellulose substances.
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Notwithstanding how, 3 patients in the 3D-CRT society required a treatment coffee-break due to toxicity, whereas no assiduous in the IMRT society required a treatment frustrate.
In light of these findings and a review of interim data on the other outcomes that were available to them (but that remain unavailable to the investigators and all others), the independent data and safety monitoring committees of both SHARP and IMPROVE-IT have recommended that those trials continue to their scheduled end dates early in the next decade.
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About half the apparent excess incidence of cancer in the SEAS trial was observed within 2 years after treatment was started, during which period there were more than five times the number of patients with cancer in SHARP and IMPROVE-IT as in the SEAS study, without any apparent excess ().
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Of the prespecified secondary end points, only stroke and nonfatal stroke were statistically significantly reduced by intensive blood pressure treatment.
On the other hand, mixture of different glidant and lubricant such as colloidal silicon dioxide, and magnesium stearate, did not show positive effect on dissolution of ezetimibe.
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Usually within 2-3 weeks patients get the benefits from the drug.
Ultimately, the study found no significant difference in the study's primary endpoint between those taking the combination drug and those taking placebo.
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Not only are statins effective in normalizing all aspects of your cholesterol profile, they have been also noted to prevent death and complications due to cardiovascular disease.
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The UVA study, now published online in the journal Atherosclerosis, follows two major clinical studies in 2008 and 2009 that also raised doubts about the benefits of ezetimibe in patients suffering from high LDL cholesterol levels, atherosclerosis and other heart-related problems.
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Nervous system side effects including dizziness, paresthesia, and headache have been associated with ezetimibe in postmarketing experience.
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